PDRN was first used in Italy in the early 2000s as a medical treatment to heal wounds, burns, and surgical scars. Around the same time, Korean doctors began using PDRN in dermatology and plastic surgery to help patients recover faster from skin damage. Today, it’s a trusted ingredient in regenerative medicine and high-performance skincare.

PDRN activates skin repair by stimulating special receptors called A2A receptors. This triggers a healing response in your skin—boosting cell turnover, reducing inflammation, and encouraging collagen production. Clinical studies, like one published in the International Journal of Molecular Sciences in 2016, show that PDRN significantly improves skin recovery and reduces inflammation.

MC-PDRN is a cosmetic-grade version created by Morechem Co., Ltd. in South Korea. It’s made from purified salmon DNA, then broken down into smaller, skin-absorbable molecules. This form is highly stable, safe for daily use, and designed to deliver clinical-level results without irritation.

MC-PDRN increases the growth of fibroblasts, the skin cells responsible for producing collagen and elastin. In lab tests, a 10% concentration of MC-PDRN increased cell activity by up to 37%, helping skin feel firmer and more youthful.

Exposure to UV rays increases an enzyme called MMP-1, which breaks down collagen. MC-PDRN was shown to reduce MMP-1 levels by 23%, helping to preserve skin elasticity and prevent sagging.

Collagen gives your skin structure and bounce. MC-PDRN boosts the production of Procollagen Type I, the first step in building healthy collagen. In lab tests, collagen levels increased by 25% after using a 10% concentration.

PDRN has been studied for over two decades in medical settings. A 2013 clinical study published in Dermatology Research and Practice confirmed its safety and effectiveness in regenerating damaged skin. It’s commonly used after laser treatments, microneedling, and even in sensitive conditions like eczema or surgical scars.

Beyond skincare, PDRN is used in injection therapies, wound dressings, and even joint repair treatments. In Korea, it’s known as the key ingredient in popular “baby face” or “baby skin” injections, used to rejuvenate dull or aging skin.

PDRN doesn’t just hydrate your skin—it teaches your skin to repair itself. It’s a smart, science-backed way to restore elasticity, reduce wrinkles, and improve skin texture over time.

MC-PDRN remains stable under normal storage conditions (even at 45°C), with no change in color or texture. To maintain its potency, it should be stored in a cool, shaded place away from direct sunlight or UV exposure.